APP and Alzheimer disease: It is worth mentioning that APP sequential processing via secreting enzymes triggered the release of beta-amyloid into the CNS extracellular space while dysregulated levels of APP and its catabolites lead to the accumulation of insoluble amyloid plagues which trigger the production of ROS, neural cell death, and various neurological disorders including Alzheimer's disease (Westmark 2013; Zetterberg et al. 2010).