ABCB1 and congenital rubella syndrome: P-glycoprotein(P-gp) is an ATP-dependent transmembrane efflux pump that has beenshown to contribute to CRS pathogenesis.1,2 Our group hasdemonstrated P-gp overexpression in the sinus epithelium of CRS patientswith Type 2 inflammation.1,2 We have also shown itsrole in modulating epithelial proinflammatory cytokines secretion.3−5