Second, it is well‐known that PRNP genotype (codon 129 polymorphism) and the molecular subtype of the native prion protein (PrPC) affect multiple aspects of prion disease, including clinical presentation, incubation period, and pathological phenotype;48, 49 however, the codon 129 genotype and molecular subtype of the six healthy participants used for the microarray expression analysis are unknown. The gene discussed is PRNP; the disease is prion disease.