Prostate-specific antigen (PSA) screening for PCa, although controversial because of the associated false-positive results, overdiagnosis, overtreatment and the related complications,11 remains a practical method of early detection, early treatment and prevention of metastatic disease and complication,12 especially in Africa where there is higher mortality compared with other regions of the world.13 Here, KLK3 is linked to posterior cortical atrophy.