PHLDA3 and colon carcinoma: While it remains unclear whether PHLDA3 functions in vivo to regulate the AKT activity in intestinal regeneration, frequent mutations and copy number variation in the Phlda3 gene were found in colon carcinoma (https://cancer.sanger.ac.uk/cosmic), which highlights a potential role of PHLDA3 in regulating intestinal homeostasis.