MARCHF7 and Bardet-Biedl syndrome: Several E3 ubiquitin ligases have been found to be recruited at the ciliary compartment during receptor activation, including TRIM32/BBS11, a Really Interesting New Gene (RING) E3 ligase mutated in BBS patients, and axotrophin/MARCH7, a membrane‐bound RING E3 ubiquitin ligase regulating cilia loss via ubiquitylation and degradation of nephrocystin 5 (NPHP5; Das et al, 2017).