TRPV2 and melanoma: Knowing that mechanically induced rearrangements of actin depend on TRPV2 during axonal outgrowth (Sugio et al, 2017), and that intracellular Ca2+ increments have been shown to promote actin assembly to improve melanoma cell migration (Baljinnyam et al, 2010), we postulated that in nascent adhesion, the mechanical stimulation of TRPV2 signaling contributes to F‐actin bundles structure stabilization, by promoting cofilin‐1 inactivation.