While very low levels of TRPV2 mRNAs were present in normal human epithelial melanocytes (NHEM), a gradual increase in TRPV2 transcripts correlated with the rise of BRN2 expression in melanoma cells (ranging from the noninvasive 501mel, to the superficial spreading melanoma WM793, then to the metastatic melanoma WM266.4 and 451Lu; Herlyn et al, 1990; Juhasz et al, 1993; Arozarena et al, 2011a; Arozarena et al, 2011b; Tichet et al, 2015; Arozarena & Wellbrock, 2017) (Fig 1H and Appendix Fig S1D). This evidence concerns the gene TRPV2 and metastatic melanoma.