A combination of proximity‐ligation assays and spatial distribution analysis of molecules by dual‐color direct stochastic optical reconstruction microscopy (dSTORM) on migrating melanoma cells, confirmed the preferential co‐clustering of TRPV2 channels with paxillin‐ rather than vinculin‐containing structures (Fig 4B and C). The gene discussed is TRPV2; the disease is melanoma.