Although, TRPV2 overexpression increased the growth rate of the noninvasive 501mel cells, TRPV2 silencing had no impact on cell viability or ERK phosphorylation in both metastatic cell lines, suggesting that TRPV2 is dispensable for malignant melanoma proliferative/survival behavior (Fig EV1A and B). Here, TRPV2 is linked to melanoma.