To determine whether resting Ca2+ entries directly depend upon TRPV2 function in advanced melanoma, we modulated TRPV2 expression in three selected cell lines with well‐defined, but opposite invasive phenotypes (Fig 1H, Appendix Fig S1D; Herlyn et al, 1990; Juhasz et al, 1993; Arozarena et al, 2011a; Arozarena et al, 2011b; Tichet et al, 2015; Arozarena & Wellbrock, 2017). Here, TRPV2 is linked to melanoma.