Another network pharmacology research showed that the top two compounds of HSBDG, baicalein and quercetin, may play a therapeutic role on COVID-19 by mainly regulating TNF signaling pathway, PI3K-Akt signaling pathway, NOD-like receptor signaling pathway, MAPK signaling pathway, and HIF-1 signaling pathway through ACE2 (Tao et al., 2020). Here, TNF is linked to COVID-19.