Moreover, the DEPs enriched five KEGG pathways and 136 REACTOME pathways, including the RIG−I−like receptor signaling pathway, influenza A, hepatitis C, measles, coronavirus disease—COVID−19 in KEGG and interferon signaling, interferon alpha/beta signaling, antiviral mechanism by IFN−stimulated genes, and ISG15 antiviral mechanism in REACTOME (Supplementary Tables S1C,D; Figures 2C, D). The gene discussed is ISG15; the disease is hepatitis C virus infection.