The KEGG enrichment analysis result of transcriptome-proteome-metabolome combination revealed that 11 common pathways were significantly enriched by DEGs, DEPs, and DEMs, including pyrimidine metabolism, FoxO signaling pathway, proteoglycans in cancer, PI3K-Akt signaling pathway, chemical carcinogenesis-ROS, Kaposi sarcoma-associated herpesvirus infection, COVID-19, mitophagy-animal, p53 signaling pathway, chemical carcinogenesis-receptor activation, and ferroptosis (Supplementary Table S3A, Supplementary Figure S4), and 138 genes were found (Supplementary Table S3B). Here, TP53 is linked to cancer.