We also found that membrane molecules, such as leucine-rich repeat-containing protein (LRRC15), integrin alpha-11 (ITGA11), sphingosine kinase 1 (SPHK1) and fibroblast activation protein (FAP) were specifically expressed in CSFs, which could be used as therapeutic targets in CSF-targeting cancer treatment. The gene discussed is SPHK1; the disease is cancer.