In addition, another study reported that COL11A1 could induce the expression and secretion of TGF-β3 in ovarian cancer cells through NFκB/IGFBP2 axis, which then promote the transformation of ovarian fibroblasts into CAFs, at the same time, COL11A1 could also induce CAFs to secrete IL-6, thus to promote ovarian cancer cell growth and invasion (Wu et al., 2021). This evidence concerns the gene IGFBP2 and ovarian cancer.