DHCR7 and viral infectious disease: Specifically, elevated cellular 7-DHC levels, due to deficiency of 7-DHC reductase (DHCR7) or exogenous supplementation of 7-DHC, activated PI3K/AKT3, which contributed to increased IRF3 phosphorylation and type I IFN responses upon viral infections (Xiao et al., 2020).