They ligated the left carotid artery of rats for 8 weeks and found that 8 weeks of chicoric acid (50 mg/kg/d) gavage significantly inhibited carotid intimal hyperplasia and reduced the intima area of the injured carotid artery; western blot analysis showed that chrysotile acid decreased p-mTOR and p-P70S6K protein levels, suggesting its possible inhibition of the mTOR/P70S6K signaling pathway, which in turn hindered the VSMC phenotypic switching, proliferation, migration, and neointima formation and improving AS. The gene discussed is RPS6KB1; the disease is hyperplasia.