Its application improved survival rate in CLP model rats, and ameliorated cognitive impairment in rats with sepsis-related encephalopathy by inhibiting hippocampal synaptic damage, neuronal loss, oxidative stress, and release of inflammatory cytokines trough activation of the Nrf-2/HO-1 pathway and hippocampal α7 nicotinic acetylcholine receptors (Han et al., 2018; Li C et al., 2020). The gene discussed is NFE2L2; the disease is Sepsis.