MAP2K4 and Sepsis: ZT01, a triptolide derivative, showed also anti-inflammatory activity via reducing TNF-α and IL-6 levels, blocking the formation of the TGF-β-activated kinase1 (TKA1)/TAK1-binding protein1 (TAB1) complex, and inhibiting the phosphorylation of both mitogen-activated protein kinase kinase 4 (MKK4) and JNK in both in vivo and in vitro sepsis models (Fu et al., 2020).