CD8A and Sepsis: In addition, a prospective randomized controlled trial found that electroacupuncture at both ST 36 and Guanyuan (RN 4) in patients with sepsis played an immunoprotective role by reducing the APACHE II score, increasing CD3+, CD4+, CD8+ expression and the CD4+/CD8+ ratio, and increasing HLA-DR expression in lymphocytes (Yang et al., 2016).