TLR4 and acute respiratory distress syndrome: In a mouse model of LPS-induced acute lung injury (ALI), DCQD treatment inhibited TLR4/NF-κB signaling and IL-6, IL-8, and TNF-α secretion in lung tissue, and reduced pulmonary edema by upregulating aquaporin (AQP) 1/5 expression (Hu et al., 2019).