CXCL8 and acute respiratory distress syndrome: In rats with LPS-induced ALI, emodin suppressed IKKβ, p-IKKβ, p65, and p-p65 levels, decreased NF-κB DNA binding activity, and inhibited IL-8, IL-1β, TNF-α, and myeloperoxidase (MPO) expression in lung tissues, and increased the proportion of Gr1+/CD11b+ cells in bronchoalveolar lavage fluid (BALF) (Liu B et al., 2020).