GRK2 and escherichia coli infection: In a mouse model of acute E. coli peritoneal infection, AS-IV treatment alleviated peritonitis symptoms by promoting the influx of neutrophils to the infection site, an effect mediated by inhibition of G protein-coupled receptor kinase-2 (GRK2) expression and subsequent blockade of LPS-induced suppression of CXC motif chemokine receptor 2 (CXCR2) on neutrophils (Huang et al., 2016).