In animal models of sepsis-associated ALI and encephalopathy, the protective effect of GRg1 was shown to also depend on autophagy enhancement, via a mechanism related to the activation of Nrf-2 and inhibition of NF-κB signal transduction (Li Y et al., 2017; Ji et al., 2021). This evidence concerns the gene NFKB1 and acute respiratory distress syndrome.