GRg1 treatment also alleviated lung injury and extended survival in mice with LPS-induced ALI; experiments in LPS-challenged pulmonary epithelial A549 cells further showed that GRg1 exposure inhibited ROS production, prevented apoptosis, and reduced ER stress and inflammatory cytokine expression by upregulating Sirt1 (Wang Q.L. et al., 2019). This evidence concerns the gene SIRT1 and acute respiratory distress syndrome.