As a translational factor, the transactivation function of AR can be regulated by Specificity Protein 1 (SP1) (Chen et al., 2008), the interaction between AR and SP1 stimulated the production of Vascular Endothelial Growth Factor (VEGF) (Eisermann et al., 2013) and Erythropoietin-Producing Hepatocellular carcinoma cell surface type-A receptor 3 (EPHA3) (Diao et al., 2018), which promotes PCa growth and progession. This evidence concerns the gene SP1 and posterior cortical atrophy.