HeLa‐ACE2 cells were plated into 24‐well plates and transfected 24 h later with 1 μg crRNA and Cas13d, 24 h following which they were infected with authentic SARS‐CoV‐2(614D) at a multiplicity of infection (MOI) of 0.3 (Figure 2A,B). Here, ACE2 is linked to infection.