CYP46A1 and early-onset autosomal dominant Alzheimer disease: Interestingly, the occurrence of Alzheimer’s disease was also related to a SNP in one of the introns of CYP46A1. An OR value of 1.69, about 5-fold lower than for the association of some of the SNPs with PD found here, has been described for this disease (He et al., 2012).