For example, TMEM45A can attenuate the killing effect of drugs on glioma cells and promote malignant proliferation (Sun et al., 2015); TMEM88 promotes breast cancer invasion and migration by interacting with dishevelled (Dvl) proteins (Yu et al., 2015); TMEM45B promotes limitless proliferation of gastric cancer cells through JAK2/STAT3 (Shen et al., 2018); TMEM60 increases marbling fat in beef through the co-expression network (Lim et al., 2014) and, when combined with other genes, participates in the production and secretion of creatinine in some European bloodlines (Liu et al., 2011). This evidence concerns the gene TMEM60 and glioma.