TMEM60 and central nervous system cancer: For example, TMEM45A can attenuate the killing effect of drugs on glioma cells and promote malignant proliferation (Sun et al., 2015); TMEM88 promotes breast cancer invasion and migration by interacting with dishevelled (Dvl) proteins (Yu et al., 2015); TMEM45B promotes limitless proliferation of gastric cancer cells through JAK2/STAT3 (Shen et al., 2018); TMEM60 increases marbling fat in beef through the co-expression network (Lim et al., 2014) and, when combined with other genes, participates in the production and secretion of creatinine in some European bloodlines (Liu et al., 2011).