A recent study also showed that C10, a novel 3′,5′-diprenylated chalcone, activates Caspase-3 by inducing the protein kinase Cδ (PKCd)/c-Jun N-termital kinase (JNK) pathway, which in turn triggers cleavage of GSDME to execute pyroptosis in PCa cells (58). This evidence concerns the gene CASP3 and posterior cortical atrophy.