In the same study, Tsc2–/– MEFs treated with rapamycin or torin1 did not change the expression of PLA2G16, while the PLA inhibitor methyl arachidonyl fluorophosphonate (MAFP) reduced the growth and induced apoptosis on tuberin-deficient cells derived from LAM patient. The gene discussed is TSC2; the disease is lymphangioleiomyomatosis.