TSC1 and lymphangioleiomyomatosis: Even if GD3 expression in LAM cells and lipids accumulation in the renal angiomyolipomas of LAM patients can be considered a consequence of mTOR deregulation (63), emerging researches demonstrate the existence of uncovered TSC1/2-dependent-mTORC1-independent regulation of lipids metabolism that may contribute to the LAM pathogenesis and progression.