Interestingly, IL-8, a potent neutrophil chemotactic factor that triggers chemotaxis and neutrophil activation through a phosphorylation cascade in the inflammatory response (55), has been demonstrated to be involved in the pathogenesis and progression of lung diseases such as ARDS and SARS CoV-2, suggesting the possibility to use IL-8 as a biomarker or as a therapeutic target (56). The gene discussed is CXCL8; the disease is lung disorder.