The Venn diagram showed that there are four genes (SIK1, TWIST1, BTG2, and EGR2) that were altered in the schizophrenic model rat PFC and also are potential targets of miR-25 (Figure 1D), among which SIK1 and TWIST1 are of our particular interests, since there is no previous study reporting their associations with schizophrenia. The gene discussed is SIK1; the disease is schizophrenia.