In particular, SIK1 and SIK2 were found to be associated with neuropsychiatric disorders, such as epilepsy and depression, and inhibition of SIKs was shown to be an effective measure to treat these neuropsychiatric disorders (Hansen et al., 2015; Pröschel et al., 2017; Liu et al., 2020). This evidence concerns the gene SIK1 and depressive disorder.