The Venn diagram showed that there are four genes (SIK1, TWIST1, BTG2, and EGR2) that were altered in the schizophrenic model rat PFC and also are potential targets of miR-25 (Figure 1D), among which SIK1 and TWIST1 are of our particular interests, since there is no previous study reporting their associations with schizophrenia. This evidence concerns the gene BTG2 and schizophrenia.