Furthermore, altered Akt/GSK3β signaling was widely reported to be associated with schizophrenia (Emamian, 2012); and, it was pointed out that GSK3β can be phosphorylated at Ser9 by TWIST1 through the activation of the PI3K/Akt (Ser473) signaling (Li and Zhou, 2011). This evidence concerns the gene GSK3B and schizophrenia.