SNCA and Parkinson disease: α-synuclein is a 140 aminoacid protein, enriched in the presynaptic terminal, that under particular conditions accumulates in aggregated forms, such as oligomers, protofibrils and fibrils within the neuronal inclusions typical of PD (Spillantini et al., 1997; Garcia-Reitboeck et al., 2013; Durante et al., 2019).