Furthermore, the FKBP5 rs3800373 variant is located in the 3′ prime untranslated region and likely alters the stability and half-life of the mRNA and modulates glucocorticoid signaling and HPA axis function (Fudalej et al., 2015); this variant has been linked to symptoms directly associated with sleep disturbances such as anxiety, depression and pain (Knisely et al., 2019). This evidence concerns the gene FKBP5 and major depressive disorder.