After adjusting for age, gender, serum ALT, and AST levels, multivariate logistic regression showed that DHX58rs2074158 (Dominant model: adjusted OR = 1.53, 95% CI [1.20–1.95], P = 0.001; Additive model: adjusted OR = 1.50, 95% CI [1.27–1.78], P < 0.001) and IFIH1rs10930046 (Additive model: adjusted OR =1.26, 95% CI [1.07–1.49], P = 0.005) were significantly associated with CHC risk. The gene discussed is GPT; the disease is cryohydrocytosis.