GLP1R and diabetes mellitus: Although the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD) recommended the glucagon-like peptide 1 receptor agonist as the first choice of injectable medication for individuals with T2DM, patients’ compliance in the real-world study (RWS) is more than low, resulting in a non-negligible difference between RWS and randomized controlled trial (RCT) (5, 6, 12, 13).