GLP1R and type 2 diabetes mellitus: The most recent (July 2021) Italian guidelines for the management and treatment of T2D recommend metformin, sodium-glucose co-transporter-2 inhibitors (SLGT-2is) or glucagon-like peptide-1 receptor agonists (GLP-1RAs) as first-line treatment options in patients with T2D and previous CV events (without heart failure) (12, 13).