Results showed that in the tumor microenvironment of pancreatic cancer, GSK3B was mainly distributed in endothelial cells, malignant cells and B cells, IL18 was mainly distributed in dendritic cells, monocytes/macrophages and malignant cells, and VEGFA was mainly distributed in malignant cells, monocytes/macrophages and ductal cells (Figure S4). Here, GSK3B is linked to familial pancreatic carcinoma.