Sphingomyelinase-regulated Cer/SM balance plays a variety of roles in cancer, coronary heart disease and neurodegenerative disorders progression and prevention (16, 61, 62), To investigate whether Cer/SM can predict prediabetes and T2DM, we have carried out binary logistic regression and ROC curve analyses for Cer(d18:1/24:0), Cer(d18:1/23:0), Cer(d18:1/22:0) first. The gene discussed is CBLN1; the disease is type 2 diabetes mellitus.