We ultimately selected Cer(d18:1/24:0)/SM(d18:1/19:0) [(OR: 2.980; 95% CI:1.874-4.737 in prediabetes) and [(OR: 5.507; 95% CI: 3.233-9.379 in T2DM)] and Cer(d18:1/24:0)/SM(d18:0/16:0) [(OR: 2.883; 95% CI:1.801-4.614 in prediabetes) and (OR: 8.308; 95% CI: 4.778-14.445 in T2DM)] as one of components of an integrated biomarker model capable of predicting prediabetes and T2DM risk. The gene discussed is CBLN1; the disease is prediabetes syndrome.