Significant upregulation of STING, IRF3, TLR7, MAVS, and IFNβ expression was found in COVID-19 exposed placentas vs. controls (p<0.01 for STING, TLR7, MAVS, and IFNβ, and p<0.05 for IRF3). The gene discussed is MAVS; the disease is COVID-19.