The reason is that NPTX2 (Neuronal Pentraxin 2 gene) becomes increasingly repressed with age (66–68), and decreased NPTX2 levels are associated with cognitive decline, indicating synapse loss, as NPTX2 functions in maintaining synaptic plasticity and inhibitory-excitatory balance in the central nervous system (69–71). Here, NPTX2 is linked to Mental deterioration.