The most common mechanisms of WT predisposition include 11p15-related WT (Beckwith-Wiedemann spectrum), WT1 disorder, REST-related WT, TRIM28-related WT, and WAGR (Wilms tumor, aniridia, genitourinary anomalies, range of developmental delays) spectrum (Table 3). This evidence concerns the gene TRIM28 and Nephroblastoma.