Up to 12% of patients with SSc are ANCA+.20, –22 Themost common ANCA specificity identified in SSc-AAV is consistently p-ANCAwith anti-MPO in 5.9%–8% of SSc patients,21,22 while c-ANCApositivity is rare. Here, MPO is linked to anti-neutrophil cytoplasmic antibody-associated vasculitis.