In ANCA vasculitis, the HLA-DP had stronger associations with PR3-ANCA, whileMPO-ANCA was significantly associated with and HLA-DQ SNPS.31 Both GPA and MPA are closely associated with major histocompatibility complex(MHC) Class II genes, but with clear distinctions between the two. Here, PRTN3 is linked to granulomatosis with polyangiitis.