Although our study only detected statistical differences in Akt1, Pik3ca showed the same trend of alteration, and it has also been shown that BBR can reduce tau hyperphosphorylation in 3 × Tg AD mice via the Akt/glycogen synthase kinase-3β (GSK3β) pathway (Chen et al., 2020). This evidence concerns the gene PIK3CA and Alzheimer disease.