NFKB1 and bacterial infectious disease: Our results indicate that GA exacerbates macrophage apoptosis in vivo and vitro. Meanwhile, excessive inflammatory responses and NF-κB activation cause massive macrophage death and the remaining surviving macrophages in vivo are insufficient to clear sepsis-induced bacterial infections (13, 60–62), which may be an important reason for the exacerbation of bacterial infections in the blood and organs of septic mice after GA administration.