Symptoms may be musculoskeletal or neurological due to functional instability, or may be due to other issues common in G-HSD or hEDS, including but not limited to: fatigue, gastrointestinal problems, orthostatic intolerance, postural orthostatic tachycardia syndrome (POTS), urogynecological problems, mast cell activation, anxiety or depression (17). Here, CHST3 is linked to postural orthostatic tachycardia syndrome.