In this research, we obtained 10 DE-CRGs between CAD patients and normal samples by analyzing the gene expression profiles of the GSE20680 dataset, followed by combining LASSO analysis with SVM-RFE analysis, and identified 5 DE-CRGs as marker genes, including F5, MT4, RNF7, S100A12, and SORD. The gene discussed is F5; the disease is coronary artery disorder.