In the present study, we obtained 10 differentially expressed CRGs (DE-CRGs) between CAD patients and normal samples by analyzing the GSE20680 dataset and further screened out 5 disease-signature genes, including F5, MT4, RNF7, S100A12, and SORD, by combining LASSO analysis with SVM-RFE analysis, and validated in the GSE20681 and GSE42148 datasets. The gene discussed is S100A12; the disease is coronary artery disorder.