Consistent with our previous findings in human PKD1 renal cysts and mouse studies (Song et al., 2009; Leonhard et al., 2019; Malas et al., 2020), we found that Pkd1 mouse mutant kidneys displayed a rich network of up-regulated signaling pathways for protein translation, cell cycle progression, growth factors/receptors, G-protein-coupled receptors (GPCR), Rho GTPase, RAS/RAF/MAPK, as well as innate immunity and fibrosis (Supplementary Table S3). Here, PKD1 is linked to cystic kidney disease.