To address the above inconsistencies, this study explored whether sleep duration, quality were deleterious factors for rapid decline of renal function and the development of CKD in middle-aged and older Chinese adults within The China Health and Retirement Longitudinal Study (CHARLS) database, a nationally representative, longitudinal cohort with the measurements of serum creatinine and cystatin C. The gene discussed is CST3; the disease is chronic kidney disease.