MFN1 and cardiac hypertrophy: Contrary to Mfn1/Mfn2 or Drp1 cardiac knockouts, tamoxifen-inducible ablation of both fission and fusion (Mfn1/Mfn2/Drp1 triple deletion) in the adult heart produced a less deleterious cardiac phenotype characterized by concentric cardiac hypertrophy; however, the animals still died about six months post-tamoxifen[123].