ANO5 and muscular dystrophy: Additionally, an Ano5 deficiency disturbs the ability of endoplasmic reticulum to clear injury-triggered calcium accumulation, which is associated with blocked plasma membrane repair and serves as an important pathological mechanism dedicated to muscular dystrophies - limb girdle muscular dystrophy type 2L (LGMD2L) and Miyoshi myopathy type 3 (MMD3) caused by ANO5 recessive mutations (46, 47).