It is reported that ANO6, the closest paralog of ANO5, activates SLC8A1 to promote osteogenesis, in which the potential imbalance caused by SLC8A1 requires ANO6-mediated Ca2+ activated anion currents to compensate (48), and thus we speculated that an ionic equilibrium in GDD-related osteoblasts may be achieved by coordination of enhanced Slc8a1 and ANO5 gain of function of Ca2+ dependent outwardly rectifying ionic currents as reported by Anna using HEK293T cell lines (7). The gene discussed is ANO5; the disease is gnathodiaphyseal dysplasia.