Heretofore, GDD-related ANO5 missense mutations have been identified at seven positions, including p.Arg215Gly, p.Cys356Gly, p.Cys356Arg, p.Cys356Tyr, p.Cys356Phe, p.Cys360Tyr, p.Ser500Phe, p.Thr513Ile, p.Gly518Glu, and Arg597Ile (3, 9–17). The gene discussed is ANO5; the disease is gnathodiaphyseal dysplasia.