RDH8 and cancer: By Cox and LASSO regression we established a prognostic gene formula called SHMRGPI, which includes ESRRB, KDM1A, HSD3B1, PGR, AKR1C3, ARSB, RDH8, and KDM5B. KDM1A, also called LSD1, has been found to be aberrantly expressed in a variety of cancers and is closely associated with cellular effects such as epithelial-mesenchymal transition (EMT), proliferation, and malignant transformation (18).