ALB and pachyonychia congenita: The NCCN and CSCO guidelines for pancreatic adenocarcinoma (14, 22), for unresectable locally advanced PC or patients with distant metastasis, recommend GS regimen, GA regimen (GEM, albumin-bound paclitaxel), GX regimen (GEM, Capecitabine), FOLFRINOX (oxaliplatin, fluorouracil, irinotecan, and leucovorin), among others, as the first-line treatment options.