Moreover, STX1A (encoding Syntaxin-1A) is one of approximately 28 genes within a commonly deleted region in Williams Syndrome (or Williams-Beuren Syndrome, OMIM 194050), a multi-system developmental syndrome with features such as connective tissue abnormalities, cardiovascular disease, mild intellectual disability, delayed motor development, unique social and personality characteristics, and growth and endocrine abnormalities (99, 100). This evidence concerns the gene STX1A and Intellectual disability.