The results from the DiseaseMeth database further proved that KIF11 promoter is hypomethylated in bladder cancer, germ cell cancer, BLCA, ESCC, PAAD, HNSC, KICH, KIRC, LAML, LGG, OSC, OV, UCS, PA, PRAD, READ, and COAD and hypermethylated in gastric cancer, malignant pluripotent embryonal carcinoma, CHOL, ESCA, MM, GBM, LUSC, PCPG, and UCEC (Supplementary Figure 4). The gene discussed is LSS; the disease is esophageal squamous cell carcinoma.