In HLA-B-21M/X (HLA-B-21M/M and HLAB-21M/T) genotypes and upon in vitro AML blast stimulation supplemented with IL- 2, NKG2A educated NK cells presented a higher CD107a expression compared to NKG2A educated NK cells from HLA-B-21T/T (Figure 4B). Here, HLA-B is linked to acute myeloid leukemia.