AKT1 and psoriasis: PI3K/AKT signaling pathway also play an important role in the regulation of keratinocyte hyperproliferation in psoriasis (172), leading us to assume that AIM2 might regulate the proliferative state of keratinocytes in psoriasis by interacting with the PI3K/AKT signaling pathway, although the inhibitory effect of AIM2 is not very strong.