IL18 and neoplasm: However, AIM2 plays an immunosuppressive role in the melanoma microenvironment in mouse model based on that AIM2-dependent IL-1β and IL-18 promote tumor growth and that AIM2 acts as a negative regulator of the STING pathway, inhibiting STING-mediated type I IFN secretion and migration of CD8+ T cells to tumors (67).