found that AIM2 promoted oxidative phosphorylation of lipids while suppressing aerobic glycolysis in Treg cells, an effect works in part by attenuating AKT phosphorylation and the mTOR and MYC signaling pathways, rather than by the activation of the AIM2 inflammasome, Treg stability is essential for regulating autoimmune diseases (24). This evidence concerns the gene AIM2 and autoimmune disease.