AIM2-mediated secretion of IL-1β upregulates IL-17 release by T cells of a murine model of atherosclerosis, which then drives chemokines such as CXC motif chemokine ligand 1 (CXCL1) and CXCL2 to recruit more neutrophils during inflammation (87). The gene discussed is AIM2; the disease is atherosclerosis.