In malaria, deficiency of AIM2 or caspase-1 significantly reduces IL-1β production in pDCs, conventional DCs (cDCs), and macrophages, and type I IFN regulates inflammasome activation and IL-1β production, as we all know that pDCs are a major source of type I IFN so that the AIM2 inflammasome response to infection can then be cross-linked to type I IFN signaling (79). This evidence concerns the gene CASP1 and infection.