In conclusion, we identified ISG15, TNFRSF1A, GUSBP11, SERPINB1 and PTMA as potential diagnostic biomarkers of DM and we also found that these genes were significantly related to M1 macrophages, activated NK cells, Tfh cells, resting NK cells and Treg cells. The gene discussed is SERPINB1; the disease is dermatomyositis.