Electroacupuncture and iPSC-EVs treatments significantly improved neurological function and neuronal and intestinal tract injury, regulated the intestinal immunity as the levels of IL-17 and IL-10 in brain and colon tissue through MGBA and modulated the microbiota composition and diversity as well as the differential distribution of species in the intestines of the mice after cerebral ischemia−reperfusion. This evidence concerns the gene IL10 and cerebritis.