On the level of the total CD4+ and CD8+ population, we only found a few function markers or even no markers were changed in the PB and BM of patients respectively, however, further analysis of the T cell subsets revealed that the markers representing the activation and proliferation (CD38, HLA-DR, and CD69) (31, 32) were decreased in the less differentiated TN and TCM subsets in the DN-CML and TKI-F patients, while gradually recovered in the pre-MMR and MMR patients. This evidence concerns the gene CD4 and chronic myelogenous leukemia, BCR-ABL1 positive.