In the BM, CD3+ (616 cells/μl vs 1320 cells/μl P = 0.0015), CD4+ (301 cells/μl vs 671 cells/μl, P = 0.0117), and CD8+ (210 cells/μl vs 507 cells/μl, P = 0.0005) T cells were all significantly increased in DN-CML patients compared with HIs (Figure 1C). This evidence concerns the gene CD8A and chronic myelogenous leukemia, BCR-ABL1 positive.