Further, we also found a significantly increased percentage of PD-1+CD8+ TRM cells (53.50% vs 73.30%, P = 0.0409) and TIGIT+CD8+ TRM (61.40% vs 77.00%, P = 0.0465) cells in DN-CML patients compared with HIs (Figure 3D). The gene discussed is CD8A; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.