After adjusting for potential confounding factors including age, total bilirubin, cirrhosis, ACLF, vaccine types, and interval time, male sex (OR: 0.17; 95% CI: 0.06, 0.46; p<0.001) and more severe liver damage (ALT > 5×ULN) (OR: 0.30; 95% CI: 0.12, 0.71; p<0.01) were significantly associated with reduction of the probability of NAbs seropositivity (Table 2). This evidence concerns the gene GPT and Cirrhosis.