When determining the incidence of grades III to IV acute GVHD at 180 days according to these genetic groups we found that patients whose donor was homozygous for the LAG3 rs870849 T allele had the higher incidence of this complication (18.6%), patients with donors with any other LAG3 genotype but homozygous for the PDCD1 rs36084323 G allele had an intermediate incidence (12%) whereas none of the 30 patients whose donors had LAG3 rs870849 CT or CC and PDCD1 rs36084323 AG/AA genotypes developed grades III to IV acute GVHD (0%). This evidence concerns the gene PDCD1 and acute graft versus host disease.