Multivariate analysis confirmed that LAG3 rs870849 TT genotype of the donor was an independent risk factor for a higher incidence of acute GVHD, independently of the PDCD1 genotype (p: 0.031; HR: 1.76, 95%CI: 1.05 – 2.94). The gene discussed is LAG3; the disease is acute graft versus host disease.